Evaluation of Serum Kappa Free Light Chain Reference Interval Using a New Stabilized Calibrator
The new reformulated kappa FLC calibrator from The Binding Site does not support verification of the manufacturer's claimed kappa FLC RI or improve the number of healthy patients falling within the FLC ratio diagnostic range. Both the kappa FLC RI and diagnostic range for FLC ratio should be reevaluated and updated in consensus guidelines.
Authors
- Robert Maynard (ORCID: https://orcid.org/0000-0002-7590-2442)
- Derek C. Waggoner (ORCID: https://orcid.org/0000-0001-7604-039X)
- Katie Thoren (ORCID: https://orcid.org/0000-0002-0074-3344)
- Kwaku Twum
Institutions
- Boston University (US)
- University of North Carolina at Chapel Hill (US)
- University of Kentucky (US)
- University of Miami (US)
Publication Details
- Journal
- The Journal of Applied Laboratory Medicine
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1093/jalm/jfaf208
- Primary Topic
- Clinical Laboratory Practices and Quality Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00