Bayesian reanalysis to assess consistency of TALAPRO-2 results in the Japanese subgroup with metastatic castration-resistant prostate cancer

Using Bayesian evidence synthesis with prespecified borrowing levels, the Japanese subgroup results were compatible in direction and magnitude with the overall TALAPRO-2 effect. These findings reduce uncertainty around local extrapolation; a dedicated randomized study would be required to establish efficacy independently in Japanese patients.

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Publication Details

Journal
Japanese Journal of Clinical Oncology
Published
2025-12-29
DOI
https://doi.org/10.1093/jjco/hyaf219
Primary Topic
Prostate Cancer Treatment and Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Bayesian reanalysis to assess consistency of TALAPRO-2 results in the Japanese subgroup with metastatic castration-resistant prostate cancer

Kohei Hirose, Y. Fujii, Hitoshi Masuda, Motohiro Fujiwara et al.
Japanese Journal of Clinical Oncology
Prostate Cancer Treatment and Research
article

Bayesian reanalysis to assess consistency of TALAPRO-2 results in the Japanese subgroup with metastatic castration-resistant prostate cancer

Kohei Hirose, Y. Fujii, Hitoshi Masuda, Motohiro Fujiwara, Shugo Yajima, Yosuke Yasuda, Wei Chen, Hiroshi Fukushima, Akihiro Hirakawa, Soichiro Yoshida, Hajime Tanaka, Kenji Tanabe
article en

Abstract

Using Bayesian evidence synthesis with prespecified borrowing levels, the Japanese subgroup results were compatible in direction and magnitude with the overall TALAPRO-2 effect. These findings reduce uncertainty around local extrapolation; a dedicated randomized study would be required to establish efficacy independently in Japanese patients.

Japanese Journal of Clinical Oncology
Tokyo Medical and Dental University (JP), National Cancer Center Hospital East (JP), Zigong First People's Hospital (CN), The University of Tokyo (JP), Teikyo University (JP)
Openalex Percentile: Top 26%
Prostate Cancer Treatment and Research
DOISourceOpenAlex
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Bayesian reanalysis to assess consistency of TALAPRO-2 results in the Japanese subgroup with metastatic castration-resistant prostate cancer — Kohei Hirose, Y. Fujii, et al. · Japanese Journal of Clinical Oncology (2025) | TGRS Research Map | TGRS