Myocardial testosterone glucuronide and disease phenotypes in hypertrophic cardiomyopathy
DESI-IMS revealed selective accumulation of testosterone glucuronide in hypertrophied myocardium from patients needing SRT, suggesting that androgen-linked metabolic remodelling plays a role in advanced obstructive physiology in HCM.
Authors
- Ryo Omagari (ORCID: https://orcid.org/0000-0001-5558-171X)
- Ryota Sato
- Terumori Satoh
- Takenori Ikoma (ORCID: https://orcid.org/0000-0001-5521-5189)
- Keitaro Akita (ORCID: https://orcid.org/0000-0001-5395-1887)
- Kazuyuki Komatsu (ORCID: https://orcid.org/0000-0001-9861-8412)
- Atsushi Sakamoto (ORCID: https://orcid.org/0000-0002-6372-9224)
- Tomohiro Iwakura (ORCID: https://orcid.org/0000-0003-0733-0099)
- Morimasa Takayama (ORCID: https://orcid.org/0000-0001-5736-0064)
- Shuichiro Takanashi (ORCID: https://orcid.org/0000-0001-8510-0147)
- Kenichiro Suwa (ORCID: https://orcid.org/0000-0001-6934-7932)
- Keisuke Iguchi (ORCID: https://orcid.org/0000-0002-6677-2965)
- Kyoko Unno
- Md. Ariful Islam (ORCID: https://orcid.org/0000-0003-0995-2166)
- Kazuto Ohno
- Tomoaki Kahyo
- Hirotomo Saitsu
- Islam Md Monirul
- Itaru Takamisawa
- Mitsutoshi Setou
Institutions
- Harvard University (US)
- Hamamatsu Photonics (Japan) (JP)
- North South University (BD)
- Hamamatsu University School of Medicine (JP)
- Massachusetts General Hospital (US)
- Sakakibara Hospital (JP)
- Hamamatsu Photonics (United Kingdom) (GB)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1093/eschf/xvag024
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00