Langerhans Cell Histiocytosis Masquerading as Hodgkin Lymphoma

Abstract Langerhans cell histiocytosis (LCH) is a rare clonal proliferative disorder characterized by the accumulation of abnormal Langerhans-type dendritic cells1. Although it is classified as a neoplasm, it exhibits a wide spectrum of clinical presentations, ranging from isolated lesions to disseminated, multisystem involvement. LCH primarily affects the paediatric population, with the majority of cases diagnosed in children under the age of 10. However, occurrences in adults, though less frequent, have also been documented. Recent research indicates that LCH arises from myeloid precursor dendritic cells, reinforcing its characterization as a neoplastic disorder rather than a solely reactive process.2