Sodium Cantharidate Induces Apoptosis in Tongue Squamous Cell Carcinoma via p53 Targeting: Validation in Xenografts and Organoids
SCA potently inhibits TSCC progression in cell lines, xenografts, and patient-derived organoids. Its mechanism involves activation of p53 phosphorylation, shifting the BCL-2/BAX balance, and triggering caspase-dependent apoptosis. These findings position SCA as a promising therapeutic candidate and underscore the utility of organoid models in oncology drug development.
Authors
- X. Z. Li
- Lin Chen (ORCID: https://orcid.org/0000-0002-7552-8673)
- B Chen
- Chen Du (ORCID: https://orcid.org/0000-0001-6201-5257)
- Jian Meng (ORCID: https://orcid.org/0000-0002-6966-3326)
Institutions
- Xuzhou Medical College (CN)
- Xuzhou Central Hospital (CN)
Publication Details
- Journal
- Current Cancer Drug Targets
- Published
- 2026-01-08
- DOI
- https://doi.org/10.2174/0115680096393765251030065019
- Primary Topic
- Beetle Biology and Toxicology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00