Discovery of Small Molecule Inhibitors against Polo-Like Kinase 1 Targeting BreastCancer
These research findings established silymarin as a potential alternative drug targeting PLK1, which is highly expressed in HER2-positive breast cancer, and modulates the oncogenic processes not just in breast cancer, but also in other cancers.
Authors
- Venkatraman Manickam (ORCID: https://orcid.org/0000-0001-5668-100X)
- Gayatri Munieswaran
Institutions
- Vellore Institute of Technology University (IN)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2026-01-08
- DOI
- https://doi.org/10.2174/0118715206423642251022100027
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 0.00