Comparative outcomes of distal ureterectomy vs. radical nephroureterectomy in high-risk distal ureteral urothelial carcinoma: a two-center cohort study in Northern and Southern China
RNU is preferred for early-stage, low-grade cases due to its superior recurrence control, particularly for IVRFS. DU offers comparable outcomes in advanced-stage or high-grade cases, with the added advantage of renal preservation, supporting chemotherapy eligibility. Individualized treatment strategies based on patient-specific factors remain essential for optimizing outcomes in high-risk distal ureteral UC.
Authors
- Junyi Xie
- Zhoujie Sun (ORCID: https://orcid.org/0009-0007-2548-9980)
- Chunru Xu (ORCID: https://orcid.org/0000-0002-6151-0966)
- Peimin Zhou
- Xiangdong Li (ORCID: https://orcid.org/0000-0002-8669-6314)
- Zhao-fei He
- Zhiyong Li
- Zhuowei Liu
- Yunlin Ye
- Wei Yu
- Xuesong Li
- Han Hao
- Jingwei Ye
- Zhenhua Liu
Institutions
- Sun Yat-sen University (CN)
- Peking University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Sun Yat-sen Memorial Hospital (CN)
- 302 Military Hospital of China (CN)
- Gansu Provincial Hospital (CN)
- Peking University First Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1186/s12916-026-04632-2
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00