The effect of Devivit Carnitine on the functional state of the liver in rats under experimental carbon tetrachloride intoxication

The liver is a key organ responsible for maintaining homeostasis, detoxification, and metabolic balance. Among the models of experimental liver pathology, carbon tetrachloride intoxication is widely used, as it is associated with the intensive generation of free radicals, damage to hepatocyte membranes, and the development of dystrophic–necrotic processes. This study aimed to evaluate the effect of the drug Devivit Carnitine on the functional state of the liver in rats under conditions of experimental carbon tetrachloride intoxication. The experiment was conducted on laboratory animals divided into a control group and two experimental groups: the first received carbon tetrachloride, while the second received carbon tetrachloride in combination with Devivit Carnitine. The functional state of the liver was assessed by measuring alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity in blood serum. It was established that carbon tetrachloride caused a marked increase in serum ALT and AST activity, reflecting the development of pronounced cytolytic syndrome. The highest values were recorded on day 5 of the experiment, after which their levels remained elevated until the end of the study. In animals of the second experimental group, the administration of the drug contributed to a gradual decrease in transaminase activity. By day 14, ALT activity had nearly normalized, reaching values close to those of the control group, while AST activity remained slightly elevated but was significantly lower than in untreated animals. The obtained results indicate that Devivit Carnitine exhibits a pronounced hepatoprotective effect, manifested by a reduction in the intensity of cytolytic processes and partial restoration of liver functional activity. This allows it to be considered a promising agent for correcting liver pathologies induced by toxic agents.