Molecular Surveillance of Malaria in Nigeria Reveals a Low Frequency of Antimalarial Resistance Markers and Clonal Expansion of Chloroquine-Sensitive Infections

Chloroquine sensitivity at the molecular level is now dominant in Nigeria, while antifolate resistance persists. Enhanced molecular surveillance of drug resistance-associated loci will serve as an early warning to safeguard the efficacy of chemointerventions in Nigeria.

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Publication Details

Journal
Open Forum Infectious Diseases
Published
2025-12-26
DOI
https://doi.org/10.1093/ofid/ofaf719
Primary Topic
Malaria Research and Control
Type
article
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article

Molecular Surveillance of Malaria in Nigeria Reveals a Low Frequency of Antimalarial Resistance Markers and Clonal Expansion of Chloroquine-Sensitive Infections

F Patience Olusola, Nuredin Mohammed, Amambua-Ngwa Alfred, Eniyou Oriero et al.
Open Forum Infectious Diseases
Malaria Research and Control
article

Molecular Surveillance of Malaria in Nigeria Reveals a Low Frequency of Antimalarial Resistance Markers and Clonal Expansion of Chloroquine-Sensitive Infections

F Patience Olusola, Nuredin Mohammed, Amambua-Ngwa Alfred, Eniyou Oriero, Mary Aigbiremo Oboh-Imafidon, CO Falade, Umberto D’Alessandro, Olumide Ajibola, Olusola Ajibaye, Brandon Nji Amambua-Ngwa, Chinedu Ogbonnia Egwu, Martin Meremikwu, Mouhamadou Fadel Diop
article en

Abstract

Chloroquine sensitivity at the molecular level is now dominant in Nigeria, while antifolate resistance persists. Enhanced molecular surveillance of drug resistance-associated loci will serve as an early warning to safeguard the efficacy of chemointerventions in Nigeria.

Open Forum Infectious DiseasesVol. 13(1)
Funai Electric (Japan) (JP), University of Ibadan (NG), University of Calabar (NG), Abiola Ajimobi Technical University Ibadan (NG), Nigerian Institute of Medical Research (NG), Medical Research Council (GB)
Good health and well-being
Openalex Percentile: Top 23%
Malaria Research and Control
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Molecular Surveillance of Malaria in Nigeria Reveals a Low Frequency of Antimalarial Resistance Markers and Clonal Expansion of Chloroquine-Sensitive Infections — F Patience Olusola, Nuredin Mohammed, et al. · Open Forum Infectious Diseases (2025) | TGRS Research Map | TGRS