Integrating Synthesis, Pharmacological Activity, and Molecular Modelingto Explore 1,2,4-Triazine Fused Thiazolidin-4-one Derivatives as GABAAReceptor Modulators

HRSP8 demonstrated notable anticonvulsant and antioxidant activities, a wide safety margin, and strong affinity for the GABAA receptor. These findings support its potential as a lead compound for further preclinical evaluation in epilepsy therapy.

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Publication Details

Journal
CNS & Neurological Disorders - Drug Targets
Published
2026-01-08
DOI
https://doi.org/10.2174/0118715273368721251029081903
Primary Topic
Synthesis and Characterization of Heterocyclic Compounds
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article
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article

Integrating Synthesis, Pharmacological Activity, and Molecular Modelingto Explore 1,2,4-Triazine Fused Thiazolidin-4-one Derivatives as GABAAReceptor Modulators

Devender Pathak, Hariram Singh, Shikha Parmar
CNS & Neurological Disorders - Drug Targets
Synthesis and Characterization of Heterocyclic Compounds
article

Integrating Synthesis, Pharmacological Activity, and Molecular Modelingto Explore 1,2,4-Triazine Fused Thiazolidin-4-one Derivatives as GABAAReceptor Modulators

Devender Pathak, Hariram Singh, Shikha Parmar
article en

Abstract

HRSP8 demonstrated notable anticonvulsant and antioxidant activities, a wide safety margin, and strong affinity for the GABAA receptor. These findings support its potential as a lead compound for further preclinical evaluation in epilepsy therapy.

CNS & Neurological Disorders - Drug TargetsVol. 25
Dr. A.P.J. Abdul Kalam Technical University (IN), Kothiwal Dental College and Research Centre (IN), Hindu College of Pharmacy (IN), GLA University (IN)
Good health and well-being
Openalex Percentile: Top 86%
Synthesis and Characterization of Heterocyclic Compounds
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