Identification and Quantification of Structurally Related Peptide Impurity in Linaclotide by Liquid Chromatography–High Resolution Mass Spectrometry
The developed LC-HRMS method successfully addresses the challenge of determining structurally related peptide impurities in linaclotide. Its ability to characterize specific impurities provides a valuable complement to existing quality control strategies for peptide therapeutics.
Authors
- M. Li
- Wenrui Hu (ORCID: https://orcid.org/0000-0001-5514-4130)
- T Zhang
- Xinling Cui (ORCID: https://orcid.org/0000-0002-4391-5126)
- Xue Feng (ORCID: https://orcid.org/0000-0002-8444-6178)
- Peize Wu
- Xueting Dai
Institutions
- National Institute of Metrology (CN)
- Zhejiang University of Technology (CN)
- Beijing University of Chemical Technology (CN)
- China Medical University (CN)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1002/rcm.70030
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00