Extended Endocrine Therapy Following 5 Years of Adjuvant Luteinizing Hormone-Releasing Hormone Agonist in Premenopausal Patients With Node-Positive, Hormone Receptor–Positive Breast Cancer: A Cohort Study
In this cohort study analysis, extending ET in premenopausal patients with node-positive eBC after 5 years of LHRHa treatment was associated with a clinically meaningful reduction in both invasive and distant breast cancer recurrences.
Authors
- Eleonora Pagan
- Gregory John Kirkner (ORCID: https://orcid.org/0009-0005-0386-5223)
- Pier Paolo Maria Berton Giachetti (ORCID: https://orcid.org/0000-0001-5559-7279)
- Kate E. Dibble (ORCID: https://orcid.org/0000-0001-6791-2977)
- Vincenzo Bagnardi (ORCID: https://orcid.org/0000-0002-4938-3482)
- M. Regan
- Gabriele Antonarelli (ORCID: https://orcid.org/0000-0002-9758-3665)
- Jalissa Katrini (ORCID: https://orcid.org/0009-0003-1405-0586)
- Laura Boldrini (ORCID: https://orcid.org/0009-0006-0607-2154)
- Bianca Malagutti
- Elisa Giordano
- Claudia Sangalli
- Fábio Henrique Viaceli Conforti
- Monica Milano
- Elisabetta Munzone
- Grazia Castellano
- Lorenzo Guidi
- Ann H. Partridge
- Yue Zheng
- Marco Colleoni
- Dario Trapani (ORCID: https://orcid.org/0000-0003-1672-9560)
- Giuseppe Curigliano
Institutions
- Harvard University (US)
- University of Milan (IT)
- Dana-Farber Cancer Institute (US)
- Humanitas Gavazzeni (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Dana-Farber Brigham Cancer Center (US)
- European Institute of Oncology (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1200/jco-25-01660
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00