Aging macaques bridge the translational gap in perivascular space biology
The prevalence of MR-visible perivascular spaces (PVS) is age-dependent in rhesus macaques. Automated quantification in 94 male and female animals ranging 5-28 years of age demonstrated a robust association between age and PVS burden, with an anatomical distribution paralleling that of humans. Preliminary <i>ex vivo</i> validation confirmed that the MRI-detected tubular structures correspond to perivascular spaces. These findings establish the rhesus macaque as a tractable model for understanding the role of perivascular dysfunction in age-related brain vulnerability.
Authors
- Alison R. Weiss (ORCID: https://orcid.org/0000-0002-1821-8193)
- Greg Jensen (ORCID: https://orcid.org/0000-0001-5050-4360)
- Joshua Karpf (ORCID: https://orcid.org/0000-0001-6672-3445)
- Mykyta M. Chernov (ORCID: https://orcid.org/0000-0002-5301-6968)
- Avanthika Rajendran
- William A. Liguore (ORCID: https://orcid.org/0000-0002-6853-1882)
- Steven G Kohama
- Daniel L Schwartz
- Lisa C Silbert
- Randall L Woltjer
- Juan Piantino
Institutions
- Oregon National Primate Research Center (US)
- Oregon Health & Science University (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- VA Portland Health Care System (US)
- Reed College (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-15
- DOI
- https://doi.org/10.64898/2026.01.14.699534
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00