Single-cell and Bulk RNA-Seq Analyses Reveal TOMM7-mediated Multi-cell Death Mechanisms Driving Muscle-invasive Bladder Cancer Progression
TOMM7 was found to drive MIBC progression by regulating multiple cell death pathways. The MIBC.CDS may serve as a promising tool for prognostic evaluation and therapeutic stratification. Sorafenib was identified as a potential candidate for TOMM7-targeted therapy in MIBC.
Authors
- Zhe Yu (ORCID: https://orcid.org/0000-0002-6908-6135)
- Feifan Jiang
- Tanghua Li
- Zicai Zhang Zicai Zhang
- J. Zhang
- Hongfan Zhao (ORCID: https://orcid.org/0000-0001-8938-6867)
- Zheng Li (ORCID: https://orcid.org/0000-0001-6024-0194)
- Yaxian Li (ORCID: https://orcid.org/0009-0001-1221-7990)
- Yuwen Chen
- Fei Li
Institutions
- Nanfang Hospital (CN)
- Xijing Hospital (CN)
- Gaozhou People's Hospital (CN)
- Southern Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Recent Patents on Anti-Cancer Drug Discovery
- Published
- 2026-01-08
- DOI
- https://doi.org/10.2174/0115748928396718251104075645
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00