Lifestyle, Modifiable Behavioral Factors, and Biomarker Profiles in Uterine Lesions

<b>Background</b>: Precursor endometrial lesions and endometrial cancer are strongly influenced by lifestyle-related risk factors, including obesity, low physical activity, and unfavorable dietary patterns. Identifying these factors is essential for early prevention and for improving health literacy among women. <b>Objective</b>: The objective of this study was to evaluate the influence of modifiable lifestyle factors on the likelihood of developing EIN and endometrial cancer in comparison with leiomyoma. <b>Materials and Methods</b>: A cross-sectional analytical study was conducted among 50 women, divided into three groups: leiomyoma (n = 20), EIN (n = 15), and endometrial cancer (n = 15). BMI, physical activity, dietary habits, sleep duration, stress levels, and smoking status were assessed. Statistical analysis included the Kruskal-Wallis test, correlation analysis, and logistic regression. <b>Results</b>: BMI was identified as an independent predictor of EIN/EC (OR = 1.29; <i>p</i> = 0.015). Women with EIN/EC demonstrated significantly lower levels of physical activity (<i>p</i> = 0.018). A clustering of behavioral risks was observed: higher BMI was associated with higher stress and shorter sleep duration. <b>Conclusions</b>: Modifiable lifestyle factors play a key role in the development of precursor and malignant endometrial conditions. Targeted interventions focusing on weight management, increased physical activity, and improved health literacy may reduce risk and improve quality of life among peri- and postmenopausal women.