Streptococcus pyogenes and EBV coinfection in severe adult meningoencephalitis: a rare diagnosis in a diabetic patient

Intracranial coinfection involving <i>Streptococcus pyogenes</i> and EBV is exceptionally rare in adults. Early clinical manifestations are often nonspecific, yet the disease can progress rapidly, underscoring the critical importance of prompt and accurate pathogen identification. The widespread application of tNGS has significantly enhanced early diagnostic capabilities in cases of intracranial infection.