Modulatory effects of CeO2 nanoparticles on bleomycin-induced active pulmonary disease processes in animal and human airway epithelium models
In this study, inhaled CeO<sub>2</sub>NPs modulated lung injury responses in the context of active disease, with both potential protective effects and adverse outcomes. These findings demonstrate that the timing of CeO<sub>2</sub>NP exposure relative to disease progression is critical and highlight the need for hazard assessment frameworks to consider context-dependent effects, particularly in the presence of pre-existing lung injury.
Authors
- Martin O. Leonard (ORCID: https://orcid.org/0000-0003-3042-7833)
- Adam Laycock (ORCID: https://orcid.org/0000-0001-9480-5149)
- Xianjin Cui (ORCID: https://orcid.org/0000-0003-0295-429X)
- Alison Buckley (ORCID: https://orcid.org/0000-0001-5029-4121)
- Sarah Robertson (ORCID: https://orcid.org/0000-0001-9907-9289)
- Tim Gant
- Eugenia Valsami-Jones
- Chang Guo
- Rachel Smith
Institutions
- Environment Agency (GB)
- National Institute for Health and Care Research (GB)
- Public Health Scotland (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1186/s12989-026-00658-9
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health Research Health Protection Research Unit
- National Institute for Health and Care Research
- Imperial College London
- Medical Research Council
- Natural Environment Research Council