Cancer genome profiling in sarcomas: current status and future perspectives in Japan

Japan's coordinated model - CGP embedded in care, centralized data, and adaptive trial platforms - offers a blueprint for rare cancer precision medicine. Over the next five years, earlier CGP use, broader RNA-enabled diagnostics, and trial-mediated access to targeted agents should expand; coupling liquid biopsy with multi-omics and AI will refine classification and treatment selection. Addressing access and implementation gaps will be critical to translate genomic insights into better outcomes.