The differential effects of CBD and CBDA on viability and mRNA expression in colorectal cancer cells
Our findings showed that CBD exerts stronger effects on cell survival and gene expression in CRC cells than CBDA, which showed only limited activity. Moreover, the CBDA-rich C.s. extract exhibited greater efficacy than the CBDA/CBD mixture. More research is needed to further elucidate the impact of cannabinoids on CRC cell biology and signaling pathways.
Authors
- Axel Muendlein (ORCID: https://orcid.org/0000-0002-5582-4125)
- Reinhard Ertl (ORCID: https://orcid.org/0000-0001-7485-3661)
- Christine Heinzle
- Kathrin Geiger (ORCID: https://orcid.org/0009-0005-1623-3938)
- H. Drexel
- Andreas Leiherer (ORCID: https://orcid.org/0000-0003-3776-5704)
- Stella Gaenger
- Eva Maria Brandtner
- David Schmidmayr
Institutions
- University of Veterinary Medicine Vienna (AT)
- Lauder Business School (AT)
- Private University in the Principality of Liechtenstein (LI)
- Vorarlberg Institute for Vascular Investigation and Treatment (AT)
- Drexel University (US)
Publication Details
- Journal
- Journal of Cannabis Research
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1186/s42238-026-00391-2
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00