Study Design of the Akershus Cardiac Examination (ACE) 4 Study: Pragmatic Randomized Controlled Trial Assessing the Effect of Early Biomarker Measurements and Structured Feedback in Unselected Patients Hospitalized with Tachypnea

We hypothesize that early biomarker measurements and structured feedback in the patients' electronic health records using a predetermined biomarker algorithm will improve clinical outcomes in patients hospitalized with tachypnea compared to the standard of care. We will test this hypothesis in the ACE 4 study using a pragmatic, electronic health record-randomized controlled design, which enables inclusion of large patient groups in daily clinical practice.

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Publication Details

Journal
Cardiology
Published
2026-01-16
DOI
https://doi.org/10.1159/000550049
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Study Design of the Akershus Cardiac Examination (ACE) 4 Study: Pragmatic Randomized Controlled Trial Assessing the Effect of Early Biomarker Measurements and Structured Feedback in Unselected Patients Hospitalized with Tachypnea

Rahul Bhatnagar, Torbjørn Fosen Wisløff, Angelica Gjørven, Kristine Lippestad et al.
Cardiology
Sepsis Diagnosis and Treatment
article

Study Design of the Akershus Cardiac Examination (ACE) 4 Study: Pragmatic Randomized Controlled Trial Assessing the Effect of Early Biomarker Measurements and Structured Feedback in Unselected Patients Hospitalized with Tachypnea

Rahul Bhatnagar, Torbjørn Fosen Wisløff, Angelica Gjørven, Kristine Lippestad, Torbjørn Omland, Helge Røsjø, Magnus Nakrem Lyngbakken, Lars Gunnar Klæbo, Arne Didrik Høiseth
article en

Abstract

We hypothesize that early biomarker measurements and structured feedback in the patients' electronic health records using a predetermined biomarker algorithm will improve clinical outcomes in patients hospitalized with tachypnea compared to the standard of care. We will test this hypothesis in the ACE 4 study using a pragmatic, electronic health record-randomized controlled design, which enables inclusion of large patient groups in daily clinical practice.

Cardiology
University of Oslo (NO), Akershus University Hospital (NO)
Helse Sør-Øst RHF
Good health and well-being
Openalex Percentile: Top 86%
Sepsis Diagnosis and Treatment
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