Macrophage immunometabolic reprogramming impairs tissue regeneration in type 2 diabetes zebrafish model
These findings demonstrate that hyperglycemia drives immunometabolic reprogramming of macrophages, sustaining a pro-inflammatory phenotype that impairs tissue regeneration. The zebrafish T2D model provides a robust platform to investigate macrophage-driven immunometabolic mechanisms underlying defective wound healing and to explore therapeutic strategies targeting macrophage metabolism in T2D.
Authors
- Mariana Rodrigues Davanso (ORCID: https://orcid.org/0000-0003-1936-320X)
- Jordana Dinorá de Lima (ORCID: https://orcid.org/0000-0001-7186-260X)
- Tárcio Teodoro Braga (ORCID: https://orcid.org/0000-0002-2989-1076)
- Luis Eduardo Alves Damasceno (ORCID: https://orcid.org/0000-0003-2833-9244)
- Rebeca Bosso dos Santos Luz (ORCID: https://orcid.org/0000-0001-5344-5933)
- Elaine Cristina de Almeida Abreu
- Juliana Bello Baron Maurer (ORCID: https://orcid.org/0000-0001-6235-331X)
- Matheus Brandemarte Severino (ORCID: https://orcid.org/0000-0003-2124-4146)
- José Carlos Alves Filho
- André Guilherme Portela de Paula (ORCID: https://orcid.org/0000-0003-4302-2296)
- Niels Olsen Saraiva Câmara (ORCID: https://orcid.org/0000-0001-5436-1248)
- Laís Cavalieri Paredes (ORCID: https://orcid.org/0000-0001-8174-2185)
- Thaís Sibioni Berti Bastos (ORCID: https://orcid.org/0000-0002-0936-3989)
- Rilton Alves de Freitas (ORCID: https://orcid.org/0000-0002-7424-2999)
- Israel Henrique Bini
- Leonel Witcoski
- Lucas Brito de Souza Santos (ORCID: https://orcid.org/0000-0002-8712-1416)
- Prado Kb
- Amanda Girardi Somensi
- Gabriel Costa Lourenço
Institutions
- Universidade Tecnológica Federal do Paraná (BR)
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Universidade Tuiuti do Paraná (BR)
- Institute of Biomedical Science (GB)
- Universidade Federal do Paraná (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1698674
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidade de São Paulo
- Universidade Federal do Paraná
- Directorate for Biological Sciences