Acupuncture as a modulator of microglial polarization and pyroptosis in depression: evidence from a chronic unpredictable mild stress rat model
Acupuncture alleviates depression-like behaviors in CUMS-induced rats by modulating microglial polarization and inhibiting neuroinflammation-mediated pyroptosis. Our findings provide further evidence supporting acupuncture as a viable strategy for depression treatment.
Authors
- T Zhang
- Meng Li (ORCID: https://orcid.org/0000-0002-1063-7369)
- Hui Fang (ORCID: https://orcid.org/0000-0001-9365-7420)
- Jie Li (ORCID: https://orcid.org/0000-0003-0973-8645)
- Liu Ning (ORCID: https://orcid.org/0000-0002-2144-9478)
- Xinhong Wu
- Siyu Liu
- Zhuoran You
- Junliang Shen
- Muhammad Shahzad Aslam
- Yizheng Li
- Jingyu Zeng
- Chongyao Hao
- Dong Yao
- Simin Yan
- Peng Li
Institutions
- Hebei University of Engineering (CN)
- Union Hospital (HK)
- Shenzhen University (CN)
- Longyan University (CN)
- Xiamen University (CN)
- Fifth Hospital of Shijiazhuang (CN)
- 174th hospital of the People's Liberation Army (CN)
- Xiamen University Malaysia (MY)
- Affiliated Hospital of Hebei University (CN)
- Shanxi University of Traditional Chinese Medicine (CN)
- China Association of Acupuncture-Moxibustion (CN)
- Shanxi Cardiovascular Hospital (CN)
- Xiamen Medical College
Publication Details
- Journal
- Metabolic Brain Disease
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1007/s11011-025-01785-6
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00