Aberrant systemic acute-phase complement responses in conjunction with soluble CR1 attribute to varying grades of dengue disease severity
Our findings show that aberrant complement activation and levels of sCR1 could attribute to varying grades of dengue severity. Given its inverse association, the levels of sCR1 could likely render early prediction of dengue disease severity. The role of sCR1 in complement-mediated pathogenesis in dengue remains a gray area of investigation.
Authors
- Yean Kong Yong
- Marie Larsson (ORCID: https://orcid.org/0000-0002-4524-0177)
- Sivadoss Raju (ORCID: https://orcid.org/0000-0002-0524-2979)
- Abdul R. Anshad
- S. Saravanan (ORCID: https://orcid.org/0000-0002-3781-8426)
- Kannan Rajendran
- Amudhan Murugesan
- Esaki M. Shankar
- Ravindran Vighnesh
Institutions
- Linköping University (SE)
- Anna University, Chennai (IN)
- Government Medical College and Hospital (IN)
- Institut thématique Immunologie, inflammation, infectiologie et microbiologie (FR)
- Government Medical College and Hospital (IN)
- Xiamen University Malaysia (MY)
- Public Health Laboratory
- Saveetha University (IN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1731011
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Children's Medical Research
- Central University of Tamil Nadu
- Vetenskapsrådet
- Xiamen University