Beyond pruritus in Alagille syndrome: potential effects of maralixibat on fibrosis and portal hypertension–insights from two case studies
In ALGS, maralixibat treatment improved pruritus, lowered serum bile acids, and suggested potential benefits on fibrosis and portal hypertension, indicating a possible role beyond symptomatic relief.
Authors
- Simone Mameli
- María Mercadal‐Hally (ORCID: https://orcid.org/0000-0003-1687-6448)
- Jose Andrés Molino (ORCID: https://orcid.org/0000-0001-5360-1684)
- Cristina Padrós-Fornieles
- Lis Vidal-Valdivia
- Jesús Quintero-Bernabeu
- Antonio Moreno-Galdó
- Mauricio Larrarte-King
- Mar Miserachs-Barba
Institutions
- Hebron University (PS)
- Vall d'Hebron Hospital Universitari (ES)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fmed.2025.1707258
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00