Modulation of Cancer-Associated Fibroblasts via the miR-624-5p/FAP Axis Drives Progression and Metastasis in Non-Small Cell Lung Cancer
Our findings establish miR-624-5p as a novel upstream regulator that suppresses FAP expression, consequently inhibiting CAF activation and its pro-metastatic function. Targeting the miR-624-5p/FAP axis represents a promising therapeutic strategy for NSCLC metastasis.
Authors
- Ye Zhao (ORCID: https://orcid.org/0000-0001-6199-4668)
- Lihua Liu (ORCID: https://orcid.org/0000-0002-1201-4624)
- Xiaoxu Li (ORCID: https://orcid.org/0000-0003-4158-3591)
- Xiaolin Chen (ORCID: https://orcid.org/0009-0004-8784-3197)
- Xue Zhang
- Shuman Zhen
- Xinming Zhao
Institutions
- Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Cancers
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3390/cancers18020279
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00