PEGylated cerium oxide nanoparticles alleviate osteoarthritis progression by inhibiting chondrocyte ferroptosis and maintaining cartilage homeostasis
This study elucidates the previously unexplored relationship between PEG-CeONPs and ferroptosis in OA chondrocytes. PEG-CeONPs demonstrate anti-ferroptosis and chondroprotective effects by activating the NRF2 pathway, suggesting their potential as therapeutic agents for OA.
Authors
- H M Li
- Hui Zhuang (ORCID: https://orcid.org/0009-0002-0081-4322)
- Panghu Zhou
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1016/j.ejphar.2026.178563
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00