Midbrain microglial and macrophage mRNAs distinguish neuroinflammatory schizophrenia from bipolar disorder
Our findings strengthen the contention that microglia and macrophages are activated in schizophrenia and disrupted in bipolar disorder midbrains of high-inflammatory subgroups. This suggests that optimal immune-based treatments targeting schizophrenia and bipolar disorder patients may differ when restoring microglial function during inflammation.
Authors
- Maree J. Webster (ORCID: https://orcid.org/0000-0002-8778-4148)
- Adam K. Walker (ORCID: https://orcid.org/0000-0001-7954-5801)
- Iris E. Sommer (ORCID: https://orcid.org/0000-0001-5597-3262)
- Frank A. Middleton (ORCID: https://orcid.org/0000-0002-3107-7188)
- Yasmine Kostoglou
- Paul Massa
- Yunting Zhu
- Cynthia S. Weickert
- Gerardo Mendez-Victoriano
- Bart J.L. Eggen
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- SUNY Upstate Medical University (US)
- University Medical Center Utrecht (NL)
- Stanley Medical Research Institute (US)
- Neuroscience Research Australia (AU)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1016/j.bbi.2026.106276
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00