Fused and Spirocyclic Sulfones for Medicinal Chemistry via [3 + 2] Cycloaddition of Thiocarbonyl Ylide
The [3 + 2] cycloaddition between thiocarbonyl ylide CH<sub>2</sub>═S<sup>(+)</sup>-CH<sub>2</sub><sup>(-)</sup> and electron-deficient cyclic alkenes provides bicyclic sulfides. The reaction efficiently works on milligram, gram, and even multigram quantities. Standard modifications of the obtained products give fused and spirocyclic sulfones for medicinal chemistry.
Authors
- Oleksandr Stepaniuk (ORCID: https://orcid.org/0000-0003-4094-4455)
- Tymofii V. Rudenko
- Andrey A. Tolmachev
- Вадим М. Тимошенко (ORCID: https://orcid.org/0000-0002-4879-604X)
- Svitlana V. Shishkina
- Pavel K. Mykhailiuk
Institutions
- Institute of Organic Chemistry (UA)
- Enamine (Ukraine) (UA)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1021/acs.orglett.5c05431
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00