Effects of morphine self-administration on brain structure and microglial phenotypic diversity in the absence of neuronal loss in male Wistar rats

These findings suggest that morphine-induced brain volume changes during the early stages of consumption are not attributable to neuronal loss but may reflect adaptive processes involving neuronal restructuring and microglial remodeling. Microglial phenotyping emerges as a sensitive approach for detecting neuroinflammatory patterns linked to addiction vulnerability.

Authors

Institutions

Publication Details

Journal
Psychopharmacology
Published
2026-01-16
DOI
https://doi.org/10.1007/s00213-025-06994-6
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Effects of morphine self-administration on brain structure and microglial phenotypic diversity in the absence of neuronal loss in male Wistar rats

César J. Carranza‐Aguilar, David Medina-Sánchez, Mariana Stefania Serrano-Ramirez, Ana Debora Elizarraras-Herrera et al.
Psychopharmacology
Neuroinflammation and Neurodegeneration Mechanisms
article

Effects of morphine self-administration on brain structure and microglial phenotypic diversity in the absence of neuronal loss in male Wistar rats

César J. Carranza‐Aguilar, David Medina-Sánchez, Mariana Stefania Serrano-Ramirez, Ana Debora Elizarraras-Herrera, María Antonieta Carbajo-Mata, Eduardo A. Garza-Villarreal, Luis A. Trujillo-Villarreal
article en

Abstract

These findings suggest that morphine-induced brain volume changes during the early stages of consumption are not attributable to neuronal loss but may reflect adaptive processes involving neuronal restructuring and microglial remodeling. Microglial phenotyping emerges as a sensitive approach for detecting neuroinflammatory patterns linked to addiction vulnerability.

Psychopharmacology
University Medical Center Groningen (NL), Autonomous University of Queretaro (MX), University of Groningen (NL), Universidad Nacional Autónoma de México (MX)
Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
Good health and well-being
Openalex Percentile: Top 88%
Neuroinflammation and Neurodegeneration Mechanisms
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Effects of morphine self-administration on brain structure and microglial phenotypic diversity in the absence of neuronal loss in male Wistar rats — César J. Carranza‐Aguilar, David Medina-Sánchez, et al. · Psychopharmacology (2026) | TGRS Research Map | TGRS