Mitochondrial Transporter ABCB10 Protects Against Doxorubicin‐Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation
These results suggest that ABCB10 can preserve mitochondrial and diaphragm muscle function following DOX treatment by regulating iron redox-cycling and heme synthesis, independent of changes to DOX accumulation.
Authors
- Vivian Doerr (ORCID: https://orcid.org/0000-0003-2453-3197)
- Ashley J. Smuder (ORCID: https://orcid.org/0000-0001-5437-3097)
- Jie Li (ORCID: https://orcid.org/0000-0002-2335-582X)
- B. Q. H. Nguyen
- Cesar E. Jacintho Moritz
Institutions
- University of Florida (US)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1002/jcsm.70171
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health