Aspirin Downregulates PDE4D to Inhibit Malignant Progression of Osteosarcoma through the NF-κB/p65 Pathway
Aspirin suppressed the malignant progression of osteosarcoma by targeting the NF-κB/p65/PDE4D axis, positioning PDE4D as a potential therapeutic target for aspirin- based treatment strategies.
Authors
- Zhuolun Li
- Guowen Wang (ORCID: https://orcid.org/0000-0003-0945-7579)
- Houzhi Yang
- Yao Xu (ORCID: https://orcid.org/0000-0003-2171-3731)
- Jinyan Feng (ORCID: https://orcid.org/0000-0003-0972-5908)
- Peng Zhou
- Long Chen
- Chao Zhang
- Jinwu Wang
- Yan Zhang
- Yiqin Li
Institutions
- Harbin Medical University (CN)
- National Medical Products Administration (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2026-01-08
- DOI
- https://doi.org/10.2174/0109298673387686251015053130
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00