Shared and distinct spontaneous brain activity pattern in crohn’s disease and ulcerative colitis: evidence from cortical surface‑based analysis
This study identifies a common neural signature of sensory-motor dysfunction in IBD, alongside subtype-specific cortical patterns. By directly comparing CD and UC with a multimodal, surface-based approach and controlling for structural differences, our findings provide novel evidence for distinct brain-gut pathophysiology, highlighting neuroimaging as a potential tool for mechanistic insight and patient stratification.
Authors
- Shuo Huang
- Meng-Lin Huang (ORCID: https://orcid.org/0000-0002-3050-5400)
- Qinyue Luo
- Yimeng He
- Jiawei Wu
- Ping Han
- Yuting Zheng
- Heshui Shi
- Liangru Zhu
Institutions
- Union Hospital (HK)
- Precision for Medicine (United States) (US)
- State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing (CN)
- Wuhan Union Hospital (CN)
- Hubei University of Education (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1186/s12876-026-04615-w
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00