Neuropathologic Profiles and Associated Cognitive Trajectories in Community-Living Older Adults
In this cohort study, mixed neuropathologies were extremely common and complex. Compared with vascular conditions, degenerative pathologies clustered into distinct profiles. Profiles characterized by high burdens of ADNC and separately, LATE-NC and hippocampal sclerosis, had the most potent associations with cognitive decline.
Authors
- Lianlian Du
- P. A. Boyle
- Lei Yu
- Tianhao Wang
- David A. Bennett
- Julie A. Schneider
Institutions
- Rush University Medical Center (US)
- University of Illinois Chicago (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.54354
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00