Glyceryl Trinitrate versus Sham in the Treatment of Hyperacute Stroke: The Efficacy of Nitric Oxide in Stroke-2 (ENOS-2) Feasibility Randomised Controlled Trial
Recruitment limitations in this small single-centre trial prevented demonstration of feasibility for patients in the time window of 3-5 h post ictus. GTN demonstrated some evidence of PoC and was safe. A multicentre trial needs to further test this hypothesis.
Authors
- Iris Mhlanga (ORCID: https://orcid.org/0000-0003-3475-1630)
- Kailash Krishnan
- Amanda Hedstrom (ORCID: https://orcid.org/0000-0001-5763-1864)
- Tiffany L. Hamilton
- Nikola Sprigg (ORCID: https://orcid.org/0000-0002-5871-8168)
- Philip M. Bath (ORCID: https://orcid.org/0000-0003-2734-5132)
- Lucy Gray
- Camille Hutchinson
- Diane Havard
- Amanda Buck
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- Royal Derby Hospital (GB)
- Institute of Mental Health (GB)
Publication Details
- Journal
- Cerebrovascular Diseases Extra
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1159/000550499
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nottingham University Hospitals NHS Trust
- National Institute for Health and Care Research
- University of Nottingham