Modified Sanjia Powder ameliorates cognitive impairment and exerts neuroprotective effects in 5 × FAD mice: insights from quantitative proteomics
MSP confers neuroprotection in AD by modulating ACSL4-mediated lipid metabolism and oxidative stress, leading to improved cognitive function and reduced neuroinflammation in the 5 × FAD mouse model. These results position MSP as a promising therapeutic candidate for AD and demonstrate the value of quantitative proteomics in elucidating the mechanisms of traditional Chinese medicines.
Authors
- Kaifeng Wei (ORCID: https://orcid.org/0009-0000-4276-5042)
- Xiaoying Chen (ORCID: https://orcid.org/0009-0006-3849-3252)
- Y. Lynn Wang (ORCID: https://orcid.org/0000-0003-0773-1212)
- Yi Geng
- Zihan Wang (ORCID: https://orcid.org/0000-0001-8193-7054)
- Xiaoyan Zheng
- Jin Yang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Province Hospital (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fnut.2025.1699142
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00