Adhesion G protein-coupled receptors

Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly apparent. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in this field and provides a comprehensive assessment of the current understanding of aGPCR biology, including a focus on human and mammalian aGPCRs, their evolutionary origins, methodological approaches, and model systems for their investigation, as well as emerging approaches for their therapeutic targeting. SIGNIFICANCE STATEMENT: Adhesion G protein-coupled receptors are versatile cell-surface proteins that integrate structural, biochemical, and physiological functions, with major roles in health and disease. This review summarizes current knowledge of their molecular features, functions in diverse model systems, and emerging opportunities for therapeutic targeting, providing a comprehensive resource that connects basic biology with translational applications across multiple scientific disciplines.

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Journal
Pharmacological Reviews
Published
2026-01-16
DOI
https://doi.org/10.1016/j.pharmr.2026.100116
Primary Topic
Receptor Mechanisms and Signaling
Type
article
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article

Adhesion G protein-coupled receptors

Xianhua Piao, Michael Nash, Chaoyu Fu, Laurent Sabbagh et al.
Pharmacological Reviews
Receptor Mechanisms and Signaling
article

Adhesion G protein-coupled receptors

Xianhua Piao, Michael Nash, Chaoyu Fu, Laurent Sabbagh, Ana L. Moreno-Salinas, Ines Liebscher, Joseph G. Duman, Gunnar Kleinau, Robert J. Kittel, David Strutt, Garret R. Anderson, David C. Martinelli, Nicole Scholz, David M. Favara, Georgios Skiniotis, Doreen Thor, Yin Kwan Chung, Marie‐Gabrielle Ludwig, Richard Sando, Nicole A. Perry, Daniel Matúš, Antony A. Boucard, Daniel Del Toro, Simone Prömel, Anastasia Georgiadi, Signe Mathiasen, Stephen C. Blacklow, Mario Vallon, Elena Seiradake, Jinpeng Sun, Tobias Langenhan, Cheng‐Chih Hsiao, Andrew N. Dates, Sandra Berndt, Torsten Schöneberg, Kimberley F. Tolias, Douglas G. Tilley, Alain Garcia De Las Bayonas, Caroline J. Formstone, Peter W. Hildebrand, Patrick Scheerer, Dimitris G. Placantonakis, Fabian Pohl, Yimin Zou, Richard Leduc, Florian Seufert, Beatriz Blanco-Redondo, Joshua Linnert, Felix Benedikt Engel, Randy A. Hall, Uwe Wolfrum, Mareike Selcho, Mariam Melkumyan, Nathan A. Zaidman, Monserrat Avila-Zozaya, Gabriela Aust, Daniel T. Pederick, Vanhollebeke Benoit, Jörg Hamann, Hee‐Yong Kim, J.A. Mulder, Bill X. Huang, Lara-Sophie Brodmerkel, Kasturi Pal, Thomas C. Südhof, Demet Araç, James Bridges, Virginea de Araujo Farias, Yu-Qi Ping, Jonathan A. Javitch, Gregory G. Tall, Mette M. Rosenkilde, Giselle R. Wiggin, Kathleen M. Caron, Jie Yan, Erwin G. Van Meir, Norbert Sträter, Patrick Barth, Katja Spiess, David E. Gloriam, Hsi-Hsien Lin, Abhishek Kumar Singh, Sofie Morsing Bagger
article en

Abstract

Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly apparent. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in this field and provides a comprehensive assessment of the current understanding of aGPCR biology, including a focus on human and mammalian aGPCRs, their evolutionary origins, methodological approaches, and model systems for their investigation, as well as emerging approaches for their therapeutic targeting. SIGNIFICANCE STATEMENT: Adhesion G protein-coupled receptors are versatile cell-surface proteins that integrate structural, biochemical, and physiological functions, with major roles in health and disease. This review summarizes current knowledge of their molecular features, functions in diverse model systems, and emerging opportunities for therapeutic targeting, providing a comprehensive resource that connects basic biology with translational applications across multiple scientific disciplines.

Pharmacological ReviewsVol. 78(3)
Statens Serum Institut (DK), University of California, Riverside (US), University of North Carolina at Chapel Hill (US), University of Copenhagen (DK), Novartis (Switzerland) (CH), Netherlands Institute for Neuroscience (NL), National Institutes of Health (US), St. Jude Children's Research Hospital (US), Université Libre de Bruxelles (BE), Howard Hughes Medical Institute (US), Université de Sherbrooke (CA), Harvard University (US), University of Hertfordshire (GB), Johns Hopkins University (US), Emory University (US), Shandong University (CN), National University of Singapore (SG), University of New Mexico (US), Chang Gung University (TW), University of California, San Francisco (US), Friedrich-Alexander-Universität Erlangen-Nürnberg (DE), Baylor College of Medicine (US), University of Basel (CH), Johannes Gutenberg University Mainz (DE), Vanderbilt University (US), University of Würzburg (DE), University of Michigan (US), Johns Hopkins Medicine (US), Cambridge University Hospitals NHS Foundation Trust (GB), National Jewish Health (US), University of Alabama at Birmingham (US), New York Psychoanalytic Society and Institute (US), Ashoka University (IN), University of California San Diego (US), Humboldt-Universität zu Berlin (DE), University of Oxford (GB), University of Chicago (US), Baylor School (US), Amsterdam Neuroscience (NL), Boston VA Research Institute (US), Domain Therapeutics (France) (FR), Ludwig Cancer Research (CH), National Institute on Alcohol Abuse and Alcoholism (US), University Hospital Leipzig (DE), Institut d'Investigacions Biomèdiques de Barcelona (ES), University of Global Health Equity (RW), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), German Center for Diabetes Research (DE), Redx Pharma (United Kingdom) (GB), Vanderbilt Health (US), Shandong First Medical University (CN), Heinrich Heine University Düsseldorf (DE), École Polytechnique Fédérale de Lausanne (CH), University of Colorado Anschutz Medical Campus (US), New York University (US), Instituto Politécnico Nacional (MX), Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX), UConn Health (US), University of Glasgow (GB), Temple University (US), KTH Royal Institute of Technology (SE), University of Sheffield (GB), University of Colorado Denver (US), Leipzig University (DE), Stanford University (US)
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Receptor Mechanisms and Signaling
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