LY6D identifies persistent stem-like cells driving pancreatic tumourigenesis
Our work defines the LY6D<sup>+</sup> gastric-like cell state as a key driver linking early pre-malignant heterogeneity to PDAC initiation and progression. LY6D represents a pan-stage therapeutic target and a candidate biomarker for early detection and therapeutic targeting.
Authors
- X. Wang
- Zhengyan Zhang (ORCID: https://orcid.org/0000-0003-4979-9573)
- Feier Yu
- Shixin Meng
- Yongwei Sun
- Zheng Wang
- Junyi Xu
- Jing Xue
- Yingying Tang
- Juanjuan Shi
- Ping Lu
Institutions
- Renji Hospital (CN)
- Shanghai Cancer Institute (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Gut
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1136/gutjnl-2025-336460
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00