Literature review of leukoencephalopathy with calcifications and cysts and a case report

Surgical resection is an effective treatment for LCC cysts causing significant mass effect or neurological deficits, requiring regular follow-up. For smaller, asymptomatic cysts without mass effect, treatment with VEGF inhibitors (e.g., bevacizumab) may be beneficial. Management should be individualized.

Authors

Zhenwen Cui
Zechen Wang (ORCID: https://orcid.org/0000-0001-7412-4637)
Chen Shen (ORCID: https://orcid.org/0000-0002-7119-8443)
H. Li
Pin Guo
Yugong Feng (ORCID: https://orcid.org/0000-0002-5440-8197)
Chao Guan (ORCID: https://orcid.org/0009-0007-3852-3682)
Yunqing Chen
Jie Wu

Institutions

Qingdao University (CN)
Affiliated Hospital of Qingdao University (CN)

Publication Details

Journal: Frontiers in Neuroscience
Published: 2026-01-16
DOI: https://doi.org/10.3389/fnins.2026.1686818
Primary Topic: RNA regulation and disease
Type: article
Field-Weighted Citation Impact: 0.00

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article

Literature review of leukoencephalopathy with calcifications and cysts and a case report

Zhenwen Cui, Zechen Wang, Chen Shen, H. Li et al.

Jan 16, 2026

Frontiers in Neuroscience

RNA regulation and disease

article

Literature review of leukoencephalopathy with calcifications and cysts and a case report

Zhenwen Cui, Zechen Wang, Chen Shen, H. Li, Pin Guo, Yugong Feng, Chao Guan, Yunqing Chen, Jie Wu

January 16, 2026article en

Abstract

Surgical resection is an effective treatment for LCC cysts causing significant mass effect or neurological deficits, requiring regular follow-up. For smaller, asymptomatic cysts without mass effect, treatment with VEGF inhibitors (e.g., bevacizumab) may be beneficial. Management should be individualized.

Frontiers in NeuroscienceVol. 20

Qingdao University (CN), Affiliated Hospital of Qingdao University (CN)

Good health and well-being

Openalex Percentile: Top 86%

RNA regulation and disease

DOI Open Access PDF OpenAlex

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