A Genetic Brake on Blood Cancer Risk

A large genetic analysis uncovered a variant that restrains clonal hematopoiesis by slowing the growth of mutated blood stem cells linked to myeloid malignancies. The mechanisms involved may offer targets for therapies aimed at preventing cancer progression.

Publication Details

Journal
Cancer Discovery
Published
2026-01-15
DOI
https://doi.org/10.1158/2159-8290.cd-nw2026-0003
Primary Topic
Acute Myeloid Leukemia Research
Type
article
Field-Weighted Citation Impact
0.00
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article

A Genetic Brake on Blood Cancer Risk

Cancer Discovery
Acute Myeloid Leukemia Research
article

A Genetic Brake on Blood Cancer Risk

article en

Abstract

A large genetic analysis uncovered a variant that restrains clonal hematopoiesis by slowing the growth of mutated blood stem cells linked to myeloid malignancies. The mechanisms involved may offer targets for therapies aimed at preventing cancer progression.

Cancer DiscoveryVol. 16(3)
Good health and well-being
Openalex Percentile: Top 88%
Acute Myeloid Leukemia Research
DOISourceOpenAlex
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A Genetic Brake on Blood Cancer Risk · Cancer Discovery (2026) | TGRS Research Map | TGRS