Targeting SAA expression via siRNA mitigates preterm birth induced by maternal inflammation
These findings identify placental SAA2 as a key inflammatory mediator in inflammation-associated PTB and demonstrate that targeted silencing of Saa2 represents a potential therapeutic strategy to mitigate placental injury and adverse fetal outcomes.
Authors
- Anguo Liu
- Irina Burd
- Elizabeth Ann L. Enninga (ORCID: https://orcid.org/0000-0003-3621-7335)
- Courtney Townsel (ORCID: https://orcid.org/0000-0002-6650-9091)
- Jun Lei
- Kimberly Jones-Beatty
- Jin Liu
- Yang Liu
Institutions
- University of Maryland, Baltimore (US)
- Mayo Clinic (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Society for Maternal-Fetal Medicine (US)
- Mayo Clinic in Arizona (US)
- Institut de Médecine de la Reproduction (FR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fphar.2026.1749966
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00