Cerebral responses to famous face recognition as a potential functional biomarker of mild cognitive impairment

These findings suggest early alterations in PHG-PCC networks that precede observable behavioral decline in MCI. In particular, reduced activation in the left PHG may reflect early disruptions in semantic access and internally directed processing. Assessing these socially relevant neural circuits alongside established amyloid and tau biomarkers may provide complementary functional insight into early cognitive vulnerability in individuals at risk for dementia.