Preclinical Analysis of Bone Marrow-Derived Stem Cell Therapy Response and Transcriptomic Overlap Analysis in a Severe Alcoholic Hepatitis Mouse Model

MSCs therapy significantly attenuates liver injury, inflammation, and fibrosis in SAH model mice. The observed messenger RNA-protein expression mismatches highlight the complexity of molecular regulation in acute hepatitis and underscore the importance of multilevel analysis in evaluating stem cell therapy. These results provide valuable insights into the mechanisms of MSC-mediated liver repair and suggest key targets for MSC therapy and response assessment in SAH.