Dose–response relationship between cotinine levels and female reproductive lifespan
Cotinine, as an objective biomarker of tobacco exposure, was robustly associated with shortened reproductive lifespan across two national cohorts. The associations were linear, with stronger reproductive toxicity at higher exposure levels, particularly among U.S. women. These findings highlight the reproductive risks of smoking and underscore the importance of biomarker-based assessments in reproductive aging research.
Authors
- Xunmei Zhou
- Hengxi Chen (ORCID: https://orcid.org/0000-0003-4137-0801)
- Tingting Liu (ORCID: https://orcid.org/0000-0002-2636-9899)
- Jie Liao
- Xin Li
- Aijie Xie
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- Chengdu Women's and Children's Central Hospital (CN)
- Tibet Autonomous Region People's Hospital (CN)
Publication Details
- Journal
- Journal of Health Population and Nutrition
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1186/s41043-025-01229-y
- Citations
- 1
- Primary Topic
- Smoking Behavior and Cessation
- Type
- article
- Field-Weighted Citation Impact
- 32.84