Integrated Proteomic and Metabolomic Profiling for Developing Novel Plasma‐Based Diagnostic Models of Sarcopenia
We have developed high-performance plasma-based diagnostic models for sarcopenia by integrating inflammatory proteomic and metabolomic signatures. A four-biomarker model (Combined Model 2) demonstrated excellent diagnostic performance and may provide a promising clinically scalable approach for the early detection of sarcopenia.
Authors
- Haoran Jin (ORCID: https://orcid.org/0000-0002-9412-3946)
- Lu Pu (ORCID: https://orcid.org/0000-0001-5370-2557)
- Jie Yang (ORCID: https://orcid.org/0000-0003-4801-7162)
- Birong Dong
- Hao Jiang
- Yuxing Dong
- Meng Wu
- Rui Ou
- Dongqin Xu
- Fengjuan Hu
- Zhiliang Zuo
Institutions
- Sichuan University (CN)
- Chengdu Sport University (CN)
- West China Hospital of Sichuan University (CN)
- Sichuan Cancer Hospital (CN)
- New York Life Insurance Company (United States) (US)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1002/jcsm.70188
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sichuan University
- West China Hospital, Sichuan University