The imbalance of Th17/Treg cells exists in asymptomatic hyperuricemia (the early stage of gout)

Our study highlights significant alterations in lymphocyte subsets in aHUA, emphasizing their potential role in the immune response and providing insights for future therapeutic strategies. Key Points • Th17 elevation and Th17/Treg imbalance in asymptomatic hyperuricemia (aHUA) suggest early immune dysregulation. • Th17 cell levels and GGT are positively associated with acute gout flares, serving as biomarkers of disease activity. • Both aHUA and gout patients show immune activation, while there were immunological differences across groups.