A mobile system for whole eye perfusion supporting retinal function and surgery
Qualitative imaging and electroretinography confirmed post-enucleation retinal blood supply and neuronal function in perfused Yucatan mini pig eyes. Retinal surgery was performed in perfused eyes. A pilot study showed the applicability of the minipig enucleation and perfusion protocol in donated human tissue. Future validation studies of the ASTHER platform will quantify perfused tissue structure and function.
Authors
- Oliver M. Beale
- Chiaki Komatsu
- Hamzah Aweidah (ORCID: https://orcid.org/0000-0003-4667-2390)
- Maxwell Lohss (ORCID: https://orcid.org/0000-0003-2308-6022)
- Leah C. Byrne (ORCID: https://orcid.org/0000-0002-3229-4993)
- Alkiviades Liasis
- Ethan Rossi
- Sanjeev G. Shroff
- José A. Sahel
- Daniel M. W. Lee
- S. Tonya Stefko
- Katelin S. Samski
Institutions
- Institut de la Vision (FR)
- University of Pittsburgh (US)
- University of Michigan (US)
- Centre hospitalier national d'ophtalmologie des Quinze-Vingts (FR)
- Sorbonne Université (FR)
- Centre National pour la Recherche Scientifique et Technique (CNRST) (MA)
- McGowan Institute for Regenerative Medicine (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fbioe.2025.1699876
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pittsburgh