Targeted TP53 and KRAS Modulation Via AuNP-Mediated RNA Delivery Suppresses Cancer Progression
These findings demonstrate that AuNP-mediated co-delivery of siRNA and saRNA effectively modulates the KRAS-p53 signaling axis and enhances therapeutic potential in KRASmutant, TP53-wild-type cancers. Further studies, including in vivo investigations, are warranted to evaluate the translational feasibility and clinical relevance of this combinatorial approach.
Authors
- Muhammed Mücahid Dündar
- Enes Gültekin (ORCID: https://orcid.org/0000-0002-8545-1868)
- A. Koç
- İrem Nur Menevşe (ORCID: https://orcid.org/0009-0004-3497-8397)
- Dilek Çam Derin
Institutions
- Inonu University (TR)
Publication Details
- Journal
- Current Gene Therapy
- Published
- 2026-01-08
- DOI
- https://doi.org/10.2174/0115665232425141251028050552
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00