Cycloruthenated Imines: A Step into the Nanomolar Region
A new series of promising and easily accessible antiproliferative agents based on cycloruthenated imines of benzene and thiophene carbaldehydes has been developed and fully characterized using UV-Vis spectroscopy, X-ray diffraction, NMR, HRMS, and cyclic voltammetry. The biological activity of these compounds was tested against A2780, cisplatin-resistant A2780, and HEK293 cell lines, and they exhibited nanomolar IC<sub>50</sub> values. They also showed a selectivity index of up to 2.5, indicating their potential as promising antiproliferative compounds.
Authors
- Ilya A. Shutkov (ORCID: https://orcid.org/0000-0003-0069-8747)
- A. L. Nazarov
- Ksenia M. Voroshilkina
- Pavel G. Shangin
- А. Н. Васильев (ORCID: https://orcid.org/0000-0002-1886-9404)
- Алексей В. Медведько (ORCID: https://orcid.org/0000-0002-8731-6934)
- Ivan I. Troshin
Institutions
- Lomonosov Moscow State University (RU)
- N.D. Zelinsky Institute of Organic Chemistry (RU)
- MIREA - Russian Technological University (RU)
Publication Details
- Journal
- Molecules
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3390/molecules31020315
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation