White matter microstructural damage and its effect on cognitive impairment in patients with metabolic syndrome and cerebral small vessel disease
Our findings suggest that WM microstructural damage may account for the association between CSVD and cognitive impairment, acting as a potential mediator in MetS patients. Future longitudinal studies are needed to validate these findings and explore causal mechanisms.
Authors
- X. Ronald Zhu (ORCID: https://orcid.org/0009-0003-4131-2916)
- Lei Zhao (ORCID: https://orcid.org/0000-0002-5884-2708)
- Daping Lv
- Kaigui Wang
- Yu Xia (ORCID: https://orcid.org/0000-0002-3483-3727)
- Wenhui Zheng (ORCID: https://orcid.org/0009-0000-2767-3617)
- Han Liu
- Yali Chen (ORCID: https://orcid.org/0009-0007-7829-8002)
- Zhongwu Sun
- Wei Zhang
- He Feng
- Bo Tian
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
- Anhui Mental Health Center (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-01-16
- DOI
- https://doi.org/10.3389/fneur.2025.1698280
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui Medical University