Predictors of etiology and drug resistance in children with new‐onset focal seizures
This study looked at children who had focal seizures for the first time. In many cases, the cause was unknown, but a large portion was linked to structural brain changes, childhood epilepsies that usually resolve, or genetic, inflammatory, and metabolic conditions. Children with a known cause, especially genetic, structural, or inflammatory, were more likely to have seizures that did not improve with anti-seizure medications. Identifying the cause early can help doctors choose better treatments and provide closer monitoring for patients.
Authors
- Byoung Chan Lee (ORCID: https://orcid.org/0000-0003-0099-0617)
- Elizabeth Helen Barnes (ORCID: https://orcid.org/0000-0001-7435-5128)
- Deepak Gill
- Russell C. Dale (ORCID: https://orcid.org/0000-0002-2495-1826)
- Kavitha Kothur (ORCID: https://orcid.org/0000-0002-0109-8877)
- Sarmad Mohammad
- Chong Wong (ORCID: https://orcid.org/0000-0002-9476-5332)
- Sachin Gupta
Institutions
- The University of Sydney (AU)
- Children's Hospital at Westmead (AU)
- Westmead Hospital (AU)
- UNSW Sydney (AU)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2026-01-16
- DOI
- https://doi.org/10.1002/epi4.70179
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council
- National Health and Medical Research Council